Formulation: A solid
Formal Name: (3Z,6R,7R)-rel-3-butylidene-4,5,6,7-tetrahydro-6,7-dihydroxy-1(3H)-isobenzofuranone
Purity: ≥98%
Formula Markup: C12H16O4
Formula Weight: 224,3
Shelf life (days): 1460
CAS Number: 94596-28-8
Notes: Senkyunolide I is a phthalide that has been found in L. chuanxiong and has diverse biological activities.{68358,68360,68361,68362} It inhibits TNF-α-induced NF-κB reporter gene expression in HEK293 cells and reduces LPS-induced IL-8 and IL-6 production in THP-1 cells when used at a concentration of 100 µM.{68358} In vivo, senkyunolide I (32 mg/kg) reduces acetic acid-induced writhing and increases the latency to paw withdrawal in the hot plate test in mice.{68361} Senkyunolide I (36 mg/kg, i.p.) increases survival, decreases plasma levels of TNF-α, IL-1β, and IL-6, and protects against cognitive dysfunction in a mouse model of sepsis induced by cecal ligation and puncture (CLP).{68362}
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