Formulation: A solid
Formal Name: 4-[[(4-cyclohexylphenyl)methyl][2-[methyl[(2,3,4,5,6-pentafluorophenyl)sulfonyl]amino]acetyl]amino]-N-hydroxy-benzamide
Purity: ≥95%
Formula Markup: C29H28F5N3O5S
Formula Weight: 625,6
Shelf life (days): 1460
CAS Number: 1456632-41-9
Notes: SH5-07 is a STAT3 inhibitor (Ki = 10.46 µM).{68426} It is selective for STAT3 over STAT1 (Ki = >100 µM). SH5-07 prevents constitutively active STAT3 DNA binding in NIH3T3 fibroblast nuclear extracts (IC50 = 3.9 µM).{47057} It is cytotoxic to AR230 and imatinib-resistant AR230 chronic myeloid leukemia (CML) cells (IC50s = 8.1 and 7 µM, respectively) and a variety of glioblastoma cancer stem cells (CSCs; IC50s = 0.195-1.12 µM).{68427,68426} SH5-07 reduces tumor growth in MDA-MB-231 breast cancer and U-251MG glioblastoma mouse xenograft models when administered at doses of 3 and 5 mg/kg, respectively.{47057} It is also active against T. gondii when used at a concentration of 5 µM.{68428}
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