Formulation: A solid
Formal Name: 2-[[1-(2-phenylethenyl)-4-[(2-phenylethyl)amino]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]amino]-ethanol
Purity: ≥95%
Formula Markup: C23H24N6O
Formula Weight: 400,5
Shelf life (days): 1460
CAS Number: 1392816-46-4
Notes: SI-113 is a serum/glucocorticoid-regulated kinase 1 (SGK1) inhibitor (IC50 = 600 nM).{62993} It is selective for SGK1 over c-Src and Abl kinases at 12.5 µM.{62994} SI-113 (12.5 µM) is cytotoxic to MCF-7 breast cancer, A172 glioblastoma multiforme, and RKO colorectal adenocarcinoma cell lines. In vivo, SI-113, in combination with paclitaxel, reduces tumor volume, tumor weight, and SGK1 protein levels in a patient-derived xenograft (PDX) mouse model of ovarian cancer when administered at a dose of 9.3 mg/kg.{62996}. SI-113 (100 µg/ml) is also active against S. aureus and E. coli.{62995}
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