Formulation: A solid
Formal Name: 2,4-dihydro-5-[[(2-nitrophenyl)thio]methyl]-4-(2-propen-1-yl)-3H-1,2,4-triazole-3-thione
Purity: ≥98%
Formula Markup: C12H12N4O2S2
Formula Weight: 308,4
Shelf life (days): 1460
CAS Number: 675104-49-1
Notes: SSYA10-001 is an inhibitor of severe acute respiratory syndrome coronavirus (SARS-CoV) helicase nsp13 (IC50s = 5.3 and 5.7 µM for dsDNA and dsRNA, respectively) and the protein-protein interaction between human papillomavirus (HPV) E6 and E6-associated proteins (E6-AP; IC50 = 10 µM).{68356,68357,68359} It is selective for SARS-CoV nsp13 over hepatitis C virus (HCV) and dengue virus helicases at 2 µM.{68356} SSYA10-001 inhibits the replication of SARS-CoV in HEK293T cells, Middle East respiratory syndrome CoV (MERS-CoV) in Vero E6 cells, and mouse hepatitis virus (MHV) in mouse WM-L2 fibroblasts (EC50s = 8.95, 25, and 12 µM, respectively).{68356,68357} It decreases HPV E6-induced p53 degradation in SiHa and HeLa cells when used at concentrations of 1, 5, and 10 µM.{68359}
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