Formulation: A solid
Formal Name: 4-chloro-6-[1,5-dimethyl-4-(phenylmethyl)-1H-pyrazol-3-yl]-2-pyrimidinamine
Purity: ≥98%
Formula Markup: C16H16ClN5
Formula Weight: 313,8
Shelf life (days): 1460
CAS Number: 2810887-45-5
Notes: TDI-10229 is an inhibitor of soluble adenylyl cyclase (sAC; IC50 = 0.2 µM for the human enzyme in a cell-free assay).{51273} It is selective for sAC over the transmembrane ACs AC1-3, -5, -8, and -9 at 10 µM. TDI-10229 inhibits cAMP accumulation induced by the phosphodiesterase (PDE) inhibitor IBMX (Item No. 13347) in rodent sAC-expressing HEK293 cells (IC50 = 0.1 µM). It also inhibits capacitation-induced cAMP accumulation and protein kinase A (PKA) activation in isolated mouse and human sperm when used at a concentration of 5 µM. TDI-10229 (5 and 50 µM) prevents the acrosome reaction and fertilization of mouse sperm with mouse oocytes in vitro.
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