Formulation: A solid
Formal Name: 3-[(2-chloro-5-thiazolyl)methyl]tetrahydro-5-(methyl-d3)-N-nitro-4H-1,3,5-oxadiazin-4-imine
Purity: ≥99% deuterated forms (d1-d3)
Formula Markup: C8H7ClD3N5O3S
Formula Weight: 294,7
Shelf life (days): 1460
CAS Number: 1294048-82-0
Notes: Thiamethoxam-d3 is intended for use as an internal standard for the quantification of thiamethoxam (Item No. 25784) by GC- or LC-MS. Thiamethoxam is a neonicotinoid insecticide and a prodrug form of the neonicotinoid insecticide clothianidin (Item No. 29605).{45016,45017} It binds to nicotinic acetylcholine receptors (nAChRs) with low affinity (IC50 = 5,000 nM for housefly head membranes) and does not activate non-desensitizing nAChRs in cockroach neurons in vitro (IC50 = >3,000 nM).{45017} Thiamethoxam induces mortality in a variety of insects, including A. craccivora, M. persicae, and S. littoralis when administered in contact/feeding assays (LC80s = 12, 3, and 3 mg AI/L, respectively) and via systemic administration (LC80s = 0.8, 0.2, and 0.8 mg AI/L, respectively), as well as N. lugens and D. balteata in contact/feeding assays (LC80s = 0.8 mg AI/L for both).{45016} Thiamethoxam also induces 100% mortality of second instar larvae of the fall armyworm S. frugiperda and the tobacco budworm H. virescens in leaf-dip bioassays when used at a concentration of 200 mg/L.{45017} Formulations containing thiamethoxam have been used in the control of insects in agriculture.
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