Formulation: A crystalline solid
Formal Name: 1,5-dihydro-5-methyl-1-(5-O-phosphono-β-D-ribofuranosyl)-1,4,5,6,8-pentaazaacenaphthylen-3-amine
Purity: ≥95%
Formula Markup: C13H17N6O7P
Formula Weight: 400,3
Shelf life (days): 730
CAS Number: 61966-08-3
Notes: Triciribine phosphate is an Akt activation inhibitor and an active metabolite of the prodrug triciribine (Item No. 10010237).{68342,68343} Upon entry into cells, triciribine is metabolized to triciribine phosphate by adenosine kinase (AK).{68343} It binds to the Pleckstrin homology (PH) domain of Akt and prevents its recruitment to the plasma membrane in MDA-MB-468 cells.{68342} Triciribine phosphate reduces the proliferation of A1847 and A2780 ovarian cancer cells (IC50s = 1.6 and 18 µM, respectively).{68344} It inhibits HIV-1 reverse transcriptase activity in CEM-SS cells (IC50 = 0.04 µM), as well as herpes simplex virus 1 (HSV-1) replication in BS-C-1 cells and human cytomegalovirus (CMV) plaque formation in HFF-1 IRR cells (IC50s = 20 and 0.8 µM, respectively).{14992}
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