Formulation: A solid
Formal Name: N-[4-chloro-3-(trifluoromethyl)phenyl]-N′-[trans-4-[[5-(trifluoromethyl)-2-pyridinyl]oxy]cyclohexyl]-urea
Purity: ≥98%
Formula Markup: C20H18ClF6N3O2
Formula Weight: 481,8
Shelf life (days): 1460
CAS Number: 1394011-91-6
Notes: UC2288 is an inhibitor of cyclin-dependent kinase inhibitor (p21WAF1), a negative regulator of cell cycle progression.{65581} It reduces the protein levels and mRNA expression of p21WAF1 independently of Raf and p53, respectively, when used at a concentration of 10 µM. UC2288 (8 µM) decreases the proliferation of, and phosphorylation of EGFR and extracellular-signal-related kinases 1/2 (ERK1/2) in, CNE-2 and 5-8F nasopharyngeal cell lines.{65582} In vivo, UC2288, in combination with the telomerase inhibitor imetelstat, reduces tumor growth and induces apoptosis in an HCT116 colorectal cancer mouse xenograft model when administered at a dose of 15 mg/kg three times per week.{26776}
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