Formulation: A solid
Formal Name: N-(phenylmethyl)glycylglycylglycyl-L-phenylalanyl-L-threonylglycyl-L-alanyl-L-arginyl-L-lysyl-L-seryl-L-alanyl-L-arginyl-L-lysyl-L-arginyl-L-lysyl-L-asparaginyl-L-glutamamide, trifluoroacetate salt
Purity: ≥95%
Formula Markup: C82H138N32O21 • XCF3COOH
Formula Weight: 1908,2
Shelf life (days): 1460
Notes: UFP101 is a synthetic peptide and an antagonist of the nociceptin receptor (Ki = 0.06 nM in CHO cells expressing the human receptor).{65726} It is selective for the nociceptin receptor over the κ-opioid receptor (Ki = 204 nM in CHO cells expressing the rat receptor). UFP101 inhibits GTPγS release from the nociceptin receptor expressed in CHO cell membranes (EC50 = 1.86 nM). Intracerebroventricular administration of UFP101 (10 nmol/animal) increases the latency to tail withdrawal in the tail-flick test in mice. UFP101 (0.003, 0.03, and 0.3 mg/kg) increases survival in a mouse model of sepsis induced by cecal ligation and puncture.{65727}
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