Formulation: A solid
Formal Name: 1,2,3,5-tetrahydro-1-[2-(1-methylethoxy)ethyl]-2-thioxo-4H-pyrrolo[3,2-d]pyrimidin-4-one
Purity: ≥98%
Formula Markup: C11H15N3O2S
Formula Weight: 253,3
Shelf life (days): 1460
CAS Number: 890655-80-8
Notes: Verdiperstat is an irreversible inhibitor of myeloperoxidase (MPO; IC50 = 630 nM), a redox enzyme involved in oxidative stress.{69284} It is selective for MPO over a panel of 130 enzymes, transporters, and ion channels (IC50s = >50 µM for all).{69285} Oral administration of verdiperstat (180 µmol/kg) reduces MPO expression, prevents an increase in neuronal loss, and prevents decreases in motor score and stride length in a PLP-αSYN transgenic mouse model of multiple system atrophy, a neurological disorder characterized by motor neuron degeneration and α-synuclein aggregation in the brain.{69285}
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