Vitamin K3-d8, CAS 478171-80-1

Formulation: A solid

Formal Name: 2-methyl-d3-1,4-naphthalenedione-2,5,6,7,8-d5

Purity: ≥99% deuterated forms (d1-d8)

Formula Markup: C11D8O2

Formula Weight: 180,2

Shelf life (days): 1460

CAS Number: 478171-80-1

Notes: Vitamin K3-d8 is intended for use as an internal standard for the quantification of vitamin K3 (Item No. 15950) by GC- or LC-MS. Vitamin K3 is a synthetic form of vitamin K.{22726} It is an inhibitor of human tissue transglutaminase 2 (TGM2; IC50 = 2.2 µM). Vitamin K3 induces cell death in six neuroblastoma cell lines (IC50s = 3.18-7.09 µM), as well as human umbilical vein endothelial cells (HUVECs) and human dermal fibroblasts (HDFs; IC50s = 6.1 and 18.05, respectively).{39810} It decreases proliferation and inhibits migration in a wound healing assay in primary conjunctival fibroblasts when used at concentrations of 2, 4, or 6 mg/L.{25915} Vitamin K3 (200 µM) reduces the levels of glutathione (GSH) and increases the levels of glutathione disulfide (GSSG) and oxidized NADPH in isolated rat hepatocytes.{31225}

• SKU: CAY41285-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 41285-5
• Package Unit: 5 mg
• Quantity Unit: STK
• Application: GC-MS, LC-MS, Isotopenmarkierung