Formulation: A crystalline solid
Formal Name: N-[(1R)-1-cyclohexyl-2-[(2S)-2-[[[[4-[(hydroxyamino)iminomethyl]phenyl]methyl]amino]carbonyl]-1-azetidinyl]-2-oxoethyl]-glycine, ethyl ester
Purity: ≥98%
Formula Markup: C24H35N5O5
Formula Weight: 473,6
Shelf life (days): 1460
CAS Number: 192939-46-1
Notes: Ximelagatran is an ester prodrug of melagatran, a potent, direct, and reversible thrombin inhibitor (Ki = 1.2 nM).{27703,27704} While melagatran has poor oral bioavailability, ximelagatran displays good bioavailability resulting, in part, from rapid absorption at the gastrointestinal tract, as well as rapid onset of action.{27704} Ximelagatran is converted to melagatran by reduction and hydrolysis at the liver and other tissues.{27703,27704} It is used as an anticoagulant in a variety of situations, including thromboembolic disorders, stroke prevention in atrial fibrillation, and therapy in vein thrombosis.{27704,15996}
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