Formulation: A solid
Formal Name: 3-hydroxy-3-(methyl-d3)-pentanedioic acid
Purity: ≥99% deuterated forms (d1-d3)
Formula Markup: C6H7D3O5
Formula Weight: 165,2
Shelf life (days): 1460
CAS Number: 59060-36-5
Notes: Meglutol-d3 is intended for use as an internal standard for the quantification of meglutol (Item No. 33832) by GC- or LC-MS. Meglutol is an HMG-CoA reductase inhibitor (IC50 = 4 nM) and antimetabolite of mevalonic acid.{57645} Dietary administration of meglutol (10, 20, and 30 mg/kg per day) reduces serum total cholesterol levels in normal rats, as well as reduces them in high-cholesterol fed and hypercholesterolemic rats when administered in the drinking water at a dose of 50 mg/kg per day.{57646} It also reduces serum levels of cholesterol, triglycerides, phospholipids, and free fatty acids, as well as the severity of aortic atherosclerotic lesions, in a rabbit model of atherosclerosis induced by a high-cholesterol diet when administered at a dose of 25 mg/animal per day.{57647} Intracerebroventricular administration of meglutol (0.5 µmol/g) induces lipid peroxidation and decreases the activity of glutathione peroxidase in the cerebral cortex of one-day old rat pups.{57648} Meglutol accumulates in the tissues and fluids of patients with HMG-CoA lyase deficiency, a disorder characterized by metabolic acidosis, hypoglycemia, and lethargy.{57648}
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