Formulation: A solid
Formal Name: 3,5-dihydroxy-3-methyl-pentanoic acid, lithium salt
Purity: ≥95%
Formula Markup: C6H12O4 • XLi
Formula Weight: 148,2
Shelf life (days): 1460
CAS Number: 2618458-93-6
Notes: Mevalonate is an intermediate in the mevalonate pathway of cholesterol synthesis.{65516} It inhibits cell death induced by the HMG-CoA reductase inhibitor simvastatin (Item Nos. 10010344 / 10010345) in C2C12 myoblasts when used at concentrations ranging from 80 to 110 µM.{65515} Mevalonate (500 µM) reverses decreases in proliferation induced by the HMG-CoA reductase inhibitor lovastatin (Item No. 10010338) in several colon cancer cell lines, including RKO and SW480 cells.{65514} It increases lovastatin-induced decreases in the expression of the genes encoding Axin2, ectodermal-neural cortex 1 (ENC1), BCL2-like 1 (BCL2-L1), and cyclin D1 when used at a concentration of 500 µM. Mevalonate (50 µM) increases Rac1 protein levels, as well as increases Rac1 farnesylation induced by the arachidonic metabolite 15(S)-HETE (Item No. 34720) in human dermal microvascular endothelial cells (HDMVECs).{55558}
English
Deutsch
