Notes: Midodrine-d6 is intended for use as an internal standard for the quantification of midodrine (Item No. 17349) by GC- or LC-MS. Midodrine is a prodrug form of the α1-adrenergic receptor (α1-AR) agonist desglymidodrine.{62246} It is converted to desglymidodrine by enzymatic hydrolysis. Midodrine (5 mg/kg) increases mean arterial pressure (MAP) and decreases heart rate in normotensive rats.{29570} Formulations containing midodrine have been used in the treatment of orthostatic hypotension.