Notes: MPO-IN-28 is an adenosine A2B receptor antagonist (Ki = 2.15 µM in HEK293 cells expressing the human receptor).{67250} MPO-IN-28 is also a neuropeptide Y-like receptor 7 (NPYLR7) agonist, inducing calcium mobilization in HEK293T human kidney cells expressing mosquito (A. aegypti) NPYLR7 receptors in a reporter assay when used at a concentration of 10 µM.{67252} It inhibits blood-feeding behavior in A. aegypti mosquitos after dietary administration when used at a concentration of 100 µM. MPO-IN-28 also has been used as a synthetic intermediate in the synthesis of Gram-positive bacterial DNA polymerase III inhibitors with antibacterial activity.{67251}