Formulation: A solid
Formal Name: 1-[1-(4-methoxyphenyl)-2-(methylamino)ethyl]-cyclohexanol, monohydrochloride
Purity: ≥95%
Formula Markup: C16H25NO2 • HCl
Formula Weight: 299,8
Shelf life (days): 1460
CAS Number: 93413-90-2
Notes: (±)-N-desmethyl Venlafaxine is a minor active metabolite of the selective norepinephrine and serotonin reuptake inhibitor (SNRI) venlafaxine.{65180} It is formed from venlafaxine by the cytochrome P450 (CYP) isoform CYP3A4.{32155} (±)-N-desmethyl Venlafaxine inhibits norepinephrine and serotonin reuptake in rat synaptosome preparations (IC50s = 4.7 and 1.6 µM, respectively).{65180} In vivo, (±)-N-desmethyl venlafaxine reverses reserpine-induced hypothermia in mice with a minimum effective dose (MED) of 10 mg/kg.