NFAT Inhibitor (cell-permeable) (trifluoroacetate salt)

Formulation: A solid

Formal Name: L-arginyl-L-arginyl-L-arginyl-L-arginyl-L-arginyl-L-arginyl-L-arginyl-L-arginyl-L-arginyl-L-arginyl-L-arginylglycylglycylglycyl-L-methionyl-L-alanylglycyl-L-prolyl-L-histidyl-L-prolyl-L-valyl-L-isoleucyl-L-valyl-L-isoleucyl-L-threonylglycyl-L-prolyl-L-histidyl-L-α-glutamyl-L-glutamic acid

Purity: ≥95%

Formula Markup: C147H259N67O36S • XCF3COOH

Formula Weight: 3573,1

Shelf life (days): 1460

Notes: NFAT inhibitor (cell-permeable) is a cell-permeable form of NFAT inhibitor (Item No. 13855), an inhibitor of calcineurin-nuclear factor of activated T cells (NFAT) signaling.{69110} It inhibits the production of IL-12p40 and nitric oxide (NO) in LPS- and IFN-γ-induced mouse bone marrow-derived macrophages (BMDMs) when used at concentrations of 50 or 100 µM. NFAT inhibitor (cell-permeable) (1 mg/kg) prevents increases in kidney weight and urine albumin levels in a db/db mouse model of diabetic nephropathy.{69111} It improves fracture healing in a rat model of ovariectomy-induced osteoporosis when administered at a dose of 100 µg/kg for 16 weeks post-fracture.{69112} NFAT inhibitor (cell-permeable) (1 mg/kg) decreases disease severity in IL-10 knockout mice in a model of colitis induced by piroxicam (Item No. 13368).{69110}

• SKU: CAY36066
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 36066-1
• Green Labware: No
• Package Unit: 1 mg
• Quantity Unit: STK
• Application: Reinstoffe