Formulation: A crystalline solid
Formal Name: N-hydroxy-4-[[(1-methylethyl)[(2,3,4,5-tetrafluorophenyl)sulfonyl]amino]methyl]-benzamide
Purity: ≥98%
Formula Markup: C17H16F4N2O4S
Formula Weight: 420,4
Shelf life (days): 730
CAS Number: 2490284-25-6
Notes: NN-390 is an inhibitor of histone deacetylase 6 (HDAC6; IC50 = 9.8 nM).{62827} It is selective for HDAC6 over HDAC3, HDAC8, and HDAC11 (IC50s = >1,000 nM for all). NN-390 is cytotoxic to MV4-11 leukemia, MM.1S multiple myeloma, and HD-MB03 medulloblastoma cells (IC50s = 1.19, 1.38, and 0.13 µM, respectively).