Formulation: A solid
Formal Name: (4aS,6R,8aS)-4a,5,9,10,11,12-hexahydro-11-methyl-6H-benzofuro[3a,3,2-ef][2]benzazepine-3,6-diol
Purity: ≥90%
Formula Markup: C16H19NO3
Formula Weight: 273,3
Shelf life (days): 1460
CAS Number: 60755-80-8
Notes: O-desmethyl Galantamine is an active metabolite of the alkaloid galantamine (Item No. 17559).{62642} It is formed from galantamine by the cytochrome P450 (CYP) isoform CYP2D6.{47974} O-desmethyl Galantamine inhibits erythrocyte and brain acetylcholinesterase (AChE) and plasma butyrylcholinesterase (BChE; IC50s = 0.12, 0.5, and 24 µM, respectively). It also prevents decreases in the viability of SH-SY5Y cells induced by hydrogen peroxide, amyloid-β (25-35) (Item No. 24155), or cobalt chloride when used at concentrations ranging from 6.25 to 100 µM.{67000}