Formulation: A solid
Formal Name: 1,1′-[oxybis(methylene)]bis[4-[(hydroxyimino)methyl]-pyridinium, dichloride
Purity: ≥95%
Formula Markup: C14H16N4O3 • 2Cl
Formula Weight: 359,2
Shelf life (days): 1460
CAS Number: 114-90-9
Notes: Obidoxime is an acetylcholinesterase (AChE) modulator.{64528} It induces inhibition and activation of bovine erythrocyte AChE in the presence and absence of ACh, respectively, when used at a concentration of 3 mM. Obidoxime (10.5 mg/kg) induces reactivation of tabun-inhibited AChE in rat blood and diaphragm and reduces tabun-induced lethality in mice.{64529} Intranasal administration of obidoxime reduces seizure duration and severity and prevents mortality in a rat model of paraoxon-induced organophosphate poisoning.{64530}