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Background: S-Adenosylmethionine (AdoMet or SAM) plays a pivotal role as a methyl donor in a myriad of biological and biochemical events. It is a cofactor for enzyme-catalyzed methylations, including catechol O-methyltransferase (COMT) and DNA methyltransferases (DNMT). Although present in all cells, it is concentrated in liver where 85% of all methylation reactions occur. It is also involved in regulating liver function, growth, and response to injury.
CAS Number: 29908-03-0
Description: S-(5'-Adenosyl)-L-methionine solution. Useful as a methionine donor in methyltransferase assays.
Format: Aqueous buffer solution
Storage Stability: At least 6 months from date of receipt, when stored as directed
Supplied As: 400 µM solution in water
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)
References: 1. Chiang, P.K., et al. FASEB J. 1996 Mar;10(4):471-80.
2. Lu SC, Mato JM. Physiol Rev. 2012 Oct;92(4):1515-42.
3. Finkelstein JD. Clin Chem Lab Med. 2007;45(12):1694-9.
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