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Applications: Useful for the study of bromodomain binding assays, screening inhibitors, and selectivity profiling.
Background: Bromodomains function as acetyl-lysine binding domains, and bromodomain/ acetyl-lysine recognition can regulate histone modification, DNA replications, chromatin remodeling, and gene transcription.
Concentration: 20 µM
Description: The Bromodomain Ligand 4 is a peptide derived from histone H3 that includes an acetylated lysine. It contains a C-terminal GG linker, followed by a biotinylated Lys. This peptide is suitable for use as a ligand for several bromodomains including CREBBP.
Format: Aqueous buffer solution
Purity: ≥95%
Storage Stability: At least 6 months from date of receipt, when stored as directed
Supplied As: 20 µM aqueous solution
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)
References: Muller, S., et al. Expert Rev. Mol. Med. 2011 Sep 13;13:e29.
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