Bromodomain Non-Acetylated Ligand 1

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Amino Acid Sequence: SGRGKGGKGLGKGGAKRHRKVGG-K(Biotin)

Applications: Useful as a negative control for the study of bromodomain binding assays, screening inhibitors, and selectivity profiling.

Background: Bromodomains function as acetyl-lysine binding domains, and bromodomain/ acetyl-lysine recognition can regulate histone modification, DNA replications, chromatin remodeling, and gene transcription.

Concentration: 20 µM

Description: The Bromodomain Non-acetylated Ligand 1 is negative control for the BET Bromodomain Ligand, Cat. #33000. It is a peptide histone H4 (1-21) containing a C-terminal GG linker, followed by a biotinylated Lys. This peptide is suitable for use as a ligand for several bromodomains including members of the BET bromodomain family: BRD2, BRD3, BRD4, and BRDT.

Format: Aqueous buffer solution

Purity: ≥95%

Storage Stability: At least 6 months from date of receipt, when stored as directed

Supplied As: 20 µM aqueous solution

Warnings: Avoid freeze/thaw cycles.

Biosafety Level: Not applicable (BSL-1)

References: Park, P., et al., Am J Physiol Gastrointest Liver Physiol. 289, G1124 (2005).

• SKU: BPS33005
• Manufacturer: BPS Bioscience
• Manufacturer SKU: 33005
• Green Labware: No
• Package Unit: 0.5 ml @ 20 µM
• Quantity Unit: STK