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Application: Inhibition of furin and related endoprotease/proprotein convertase (PC1, PC2, PC4, PACE4, PC5, PC7).Useful as control inhibitor when using the Furin Protease Assay Kit (BPS Bioscience #78040).Useful when studying the role of Furin in viral fusion with BPS Bioscience Spike pseudoviruses or ACE2-HEK cell lines.
CAS Number: 150113-99-8
Description: Decanoyl-Arg-Val-Lys-Arg-chlororomethylketone, also called Subtilisin/Kex2p-like proprotein convertase inhibitor, is a small, synthetic, irreversible and cell-permeable modified RVKR peptide that inhibits the seven pro-protein convertases: furin and PC1, PC2, PC4, PACE4, PC5, PC7.
Proprotein convertases cleave proproteins to generate bioactive peptides or to activate enzymes and growth factors, thus regulating critical biological processes and playing a role in pathologies such as cancer or viral infection. Therefore, they represent potential therapeutic targets in a number of diseases.
As an inhibitor of furin, Decanoyl-RVKR-CMK blocks the fusion of flavaviruses and coronaviruses, including SARS-CoV-2, with the membrane of human host cells. It also inhibits the processing of
Format: A crystalline solid
Purity: ≥95% determined by HPLC
Solubility: Soluble in water. For obtaining a higher solubility, warm the tube at 37°C and shake it in the ultrasonic bath for a while.
Storage Stability: At least 6 months at -20°C
Supplied As: 500 µg (#78713-1) or 1 mg (#78713-2) or 5 mg (#78713-3)
Biosafety Level: Not applicable (BSL-1)
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