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Applications: Study enzyme kinetics, and screen small molecule HDAC inhibitors for drug discovery and HTS applications.
Description: A fluorogenic, acetylated peptide substrate for HDAC2, HDAC3, and HDAC6 (tested so far). This substrate fluoresces at excitation 350-380 nm, emission at 440-460 nm. It should be used in conjunction with HDAC Developer, Cat. # 50030.
Format: DMSO solution
Storage Stability: Stable at least 12 months from date of receipt, when stored as directed
Supplied As: 5 mM DMSO solution (100 µl)
Tags: AMC
Warnings: Protect from direct exposure to light. Avoid freeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)
References: 1. A. Ito et al. (2001) EMBO J. 20 1331.
2. A. Ito et al. (2002) EMBO J. 21 6236.
3. N.A. Barlev et al. (2001) Mol. Cell 8 1243.
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