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Applications: Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Biological Activity: FITC-labeled geldanamycin has been shown to inhibit HSP90 proteinwith an IC50 of 60 nM and HSP90 with an IC50 of 84 nM as shown. Measured using the HSP90 Assay Kits.
CAS Number: 30562-34-6
Concentration: 2.5 mM
Description: A novel geldanamycin fluorescent probe optimized for use with BPS's HSP90 Assay Kits. May also be used for detection of cell surface HSP90.
Format: DMSO solution (2.5 µM)
Formulation: C55H63N5O13S
Purity: ≥98%
Storage Stability: At least 6 months at -80°C.
Warnings: Avoid freeze/thaw cycles. Keep DMSO stock solutionsout of contact with air. Protect from light.
Biosafety Level: Not applicable (BSL-1)
References: 1. Kim, J., et al., Biomol. Screening 2004; 9(5): 375-381.
2. Howes, R., et al., Anal. Biochem. 2006; 350:202-213.
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