Histone H4 peptide (1-21)

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Encompassing Amino Acids: 1-21

Amino Acid Sequence: SGRGKGGKGLGKGGAKRHRKV

Applications: Useful as a substrate for histone methyltransferase (at R3) and acetyltransferase (at K5, K8, K12 and K16) family assays and for screening small molecular inhibitors of Histone 4 (R3) methyltransferases for drug discovery.

Background: Histone acetyltransferase (HAT) p300/CBP catalyses the acetylation of this N-terminal tail of free histone H4 at Lys5, 8, 12, 16. Lys8 is thought to be the preferred acetylation site in H4. A number of methyltransferases also modify this region of the histone.

Description: A peptide substrate for Histone 4 R3 methyltransferases. The peptide corresponds to amino acid residues 1-21 of histone H4.

Format: aqueous solution

Genbank: NM_003548

Purity: ≥95% by HPLC

Storage Stability: ≥ 12 months at -20°C or -70°C

Supplied As: 800 µM solution in water (200 µl)

Tags: none

Uniprot: P62805

Warnings: Avoid freeze/thaw cycles.

Biosafety Level: Not applicable (BSL-1)

References: Application Reference(s):
1. Differential mode of antimicrobial actions of arginine-rich and lysine-rich histones against Gram-positive Staphylococcus aureus (2013)
2. Extracellular histones are essential effectors of C5aR- and C5L2-mediated tissue damage and inflammation in acute lung injury (2013)

• SKU: BPS52014
• Manufacturer: BPS Bioscience
• Manufacturer SKU: 52014
• Package Unit: 160 nmole
• Quantity Unit: STK