LC-2, CAS 2502156-03-6

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CAS Number: 2502156-03-6

Description: LC-2 is a von Hippel-Lindau-based PROTAC which can degrade endogenous KRAS G12C. It covalently binds KRAS G12C with a MARTX849 warhead and recruits the E3 ligase VHL which degrades the KRAS G12C and suppresses MAPK signaling in homozygous and heterozygous KRAS G12C cell lines.

Format: Solid

Storage Stability: At least 6 months at -20°C. 

Warnings: Avoid freeze/thaw cycles

Biosafety Level: Not applicable (BSL-1)

• SKU: BPS82058
• Manufacturer: BPS Bioscience
• Manufacturer SKU: 82058
• Package Unit: 10 mg
• Quantity Unit: STK