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Applications: Study enzyme kinetics, and screen small molecular inhibitors of S-adenosyl homocysteine hydrolase and histone methyltransferases for drug discovery and HTS applications.
Background: S-Adenosyl-L-homocysteine is an amino acid derivative used in several metabolic pathways in most organisms. S-Adenosyl-L-homocysteine (SAH) is an amino acid derivative and an intermediate, by-product, or modulator of several metabolic pathways, including the activated methyl cycle and cysteine biosynthesis. SAH is formed by the demethylation of S-adenosyl-L-methionine. It is also a product of S-adenosyl-methionine (SAM)-dependent methylation of biological molecules, including DNA, RNA, and histones and other proteins. Inhibitors that block its hydrolysis are being developed as anti-viral, anti-parasitic, anti-arthritic and immunosuppressive agents.
CAS Number: 979-92-0
Description: S-(5'-Adenosyl)-L-homocysteine (AdoHCys, SAH) is a competitive inhibitor (versus AdoMet) of DNA methyltransferases. AdoHcy is used in a variety of studies on epigenetics in hyperhomocysteinemic states. EC Number: 213-560-8
Format: DMSO solution
Storage Stability: At least 6 months from date of receipt, when stored as directed
Supplied As: 400 µM solution in anhydrous DMSO
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)
References: 1. Coward JK, Slisz EP. J Med Chem. 1973 May;16(5):460-3.
2. Finkelstein JD. Clin Chem Lab Med. 2007;45(12):1694-9.
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