Clone: FCR4G8
Description of Target: MOUSE SEROBLOCK FcR
Immunogen: PU5 1.8 IOE7 Balb/c mouse cell line.
Key Reference: 1. Ivanovska, N.D et al . (2008) Properdin Deficiency in Murine Models of Nonseptic Shock. The Journal of Immunology. 180: 6962-6969.
2. Chen, H-F et al . (2009) A reduced oxygen tension (5%) is not beneficial for maintaining human embryonic stem cells in the undifferentiated state with short splitting intervals. Human Reproduction. 24: 71-80.
Product Format: Liquid. Phosphate buffered saline
Purification: Protein G Purified
Specificity#: This product is a rat antibody that recognises mouse CD16 and CD32, cell surface proteins also known as FcRgammaIII and FcRgammaII, respectively.
The function of these proteins is to bind IgG molecules via their Fc regions as part of the adaptive immune response. CD16 and/or CD32 are expressed by a wide variety of cells, including monocytes, macrophages, B lymphocytes, granulocytes, NK cells, dendritic cells and some activated T lymphocytes.
The expression of CD16/CD32 antigens can lead to non-specific binding of test monoclonal antibodies in staining procedures, resulting in œhigh background  staining on a wide range of cells. This non-specific binding may be blocked by pre-incubation of target cells with This product , resulting in clearer staining.
For direct analysis of CD16/32 expression this antibody is also available conjugated directly to FITC (MCA2305F), AlexaFluor488 (MCA2305A488), AlexaFluor647 (MCA2305A647), Biotin (MCA2305B) and RPE (MCA2305PE).
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