Formulation: A solid
Formal Name: 11β,17,21-trihydroxy-pregna-1,4-diene-3,20-dione-2,4,6,9,11,12,12-d7
Purity: ≥99% deuterated forms (d1-d7)
Formula Markup: C21H21O5D7
Notes: Prednisolone-d7 is intended for use as an internal standard for the quantification of prednisolone (Item No. 20866) by GC- or LC-MS. Prednisolone is a glucocorticoid and mineralocorticoid receptor agonist and an active metabolite of the prodrugs and synthetic glucocorticoids prednisolone phosphate (Item No. 15933) and prednisone (Item No. 20677).{25865,22687,41565} It selectively binds to the glucocorticoid and mineralocorticoid receptors over the progesterone, androgen, and estrogen receptors (Kis = 2.4, 37, >5,000, 2,762, and >1,000 nM, respectively) and induces transactivation in reporter assays using CV-1 cells expressing the human glucocorticoid receptor or human mineralocorticoid receptor (EC50s = 6.9 and 3.78 nM, respectively).{22687,41565} Prednisolone reduces pulmonary eosinophil infiltration in a rat model of sephadex-induced asthma (ED50 = 1.2 mg/kg).{22687} Formulations containing prednisolone have been used as anti-inflammatory or immunosuppressive agents.
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