Formulation: A solid
Formal Name: (1S,5R)-4-[(1E)-2-(3,4-dihydroxy-5-methoxyphenyl)ethenyl]-6,6-dimethyl-bicyclo[3.1.1]hept-3-en-2-one
Purity: ≥98%
Formula Markup: C18H20O4
Formula Weight: 300,4
Shelf life (days): 1460
CAS Number: 1454885-45-0
Notes: SP-8356 is a derivative of (1S)-(–)-verbenone and an inhibitor of CD147, also known as extracellular matrix metalloproteinase (MMP) inducer (EMMPRIN) and previously known as tumor cell-derived collagenase stimulatory factor (TCSF).{64961,64962} It inhibits the dimerization of CD147 and the protein-protein interaction between CD147 and its ligand cyclophilin A. SP-8356 (10 µM) decreases recombinant human CD147-induced migration of A-10 vascular smooth muscle cells (VSMCs) and reduces cyclophilin A-induced increases in MMP-9 activity in, and adhesion of, isolated rat monocyte-derived macrophages. It also prevents glucose-oxygen deprivation-induced increases in reactive oxygen species (ROS) and lactate dehydrogenase (LDH) release in primary rat cortical neurons in an in vitro model of ischemia when used at a concentration of 10 µM.{64963} SP-8356 (5 µM) inhibits the migration and invasion of MDA-MB-231 breast cancer cells.{64964} In vivo, SP-8356 (50 mg/kg in the drinking water) decreases plaque size in an ApoE-/- mouse model of atherosclerosis induced by partial carotid artery ligation and a high-fat diet.{64962}
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