Formulation: A crystalline solid
Formal Name: 5-(4-chloro-3-methylphenyl)-1-(4-(methyl-d3)benzyl)-N-((1S,2S,4R)-1,3,3-trimethylbicyclo[2.2.1]heptan-2-yl)-1H-pyrazole-3-carboxamide
Purity: ≥99% (dueterated forms d1-d3)
Formula Markup: C29H31D3ClN3O
Formula Weight: 479,1
Shelf life (days): 730
Notes: SR 144528-d3 is intended for use as an internal standard for the quantification of SR 144528 (Item No. 9000491) by GC- or LC-MS. SR 144528 is a cannabinoid 2 (CB2) receptor antagonist (Ki = 0.6 nM).{7912} It is selective for CB2 over CB1 receptors in CHO cells expressing the human receptors (Ki = 437 nM).{17199} SR 144528 reverses CP 55,940-induced inhibition of forskolin-induced adenylyl cyclase activity in CHO cells expressing human CB2 receptors (EC50 = 10 nM). SR 144528 (0.01 mg/kg) reduces paw swelling in a mouse model of carrageenan-induced paw edema.{14732}
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