TPP-1 (hydrochloride)

Formulation: A solid

Formal Name: L-serylglycyl-L-glutaminyl-L-tyrosyl-L-alanyl-L-seryl-L-tyrosyl-L-histidyl-L-cysteinyl-L-tryptophyl-L-cysteinyl-L-tryptophyl-L-arginyl-L-α-aspartyl-L-prolylglycyl-L-arginyl-L-serylglycylglycyl-L-seryl-L-lysine, monohydrochloride

Purity: ≥95%

Formula Markup: C107H150N34O32S2 • HCl

Formula Weight: 2525,1

Shelf life (days): 1460

Notes: TPP-1 is a peptide inhibitor of the protein-protein interaction between programmed cell death protein 1 (PD-1) and PD-1 ligand (PD-L1).{51313} It binds to PD-L1 in a cell-free assay (Kd = 94.67 nM). TPP-1 (20 µM) reverses PD-L1-induced decreases in IFN-γ levels in anti-CD3-induced isolated human CD4+ T cells. It reduces tumor volume in a mouse xenograft model using HL-60 leukemia cells co-cultured with anti-CD3-activated isolated human CD4+ T cells prior to implantation when administered at a dose of 4 mg/kg.

• SKU: CAY37410-10
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 37410-10
• Package Unit: 10 mg
• Quantity Unit: STK
• Application: Reinstoffe