Formulation: A solid
Formal Name: D-phenylalanyl-L-cysteinyl-L-tyrosyl-D-tryptophyl-L-lysyl-L-cysteinyl-L-threoninamide cyclic (2→6)-disulfide, trifluoroacetate salt
Purity: ≥98%
Formula Markup: C45H58N10O9S2 • XCF3COOH
Formula Weight: 947,1
Shelf life (days): 1460
Notes: TT-232 is a synthetic peptide derivative of somatostatin.{67113} It binds to somatostatin receptors in isolated rat synaptosomal membranes (IC50 = ~0.1 nM). TT-232 (30 and 60 µg/ml) inhibits the proliferation of P388 murine and HL-60 human leukemia cells.{67114} In vivo, TT-232 (3-12 µg/animal per day) reduces tumor volume in an HL-60 mouse xenograft model. It inhibits intradermal neutrophil accumulation and ear edema induced by capsaicin (Item Nos. 92350 / 10010743) in rats.{67115} TT-232 (5-20 µg/kg, i.p.) inhibits mechano-nociceptive hyperalgesia in rats.
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