Formulation: A solid
Formal Name: 1-(3,4-dihydroxyphenyl)-2-methyl-1-propanone
Purity: ≥95%
Formula Markup: C10H12O3
Formula Weight: 180,2
Shelf life (days): 1460
CAS Number: 5466-89-7
Notes: U-0521 is an inhibitor of catechol-O-methyltransferase (COMT; Ki = 7.8 µM for the rat liver enzyme) and tyrosine hydroxylase (IC50 = 1 µM for the rabbit adrenal enzyme).{65383,65384} It enhances epinephrine-induced contractions of isolated rabbit atria when used at a concentration of 55 µM.{65383} U-0521 (41.5 µmol/kg) also enhances isoprenaline- or epinephrine-induced increases in blood glucose levels in pancreatectomized rats.{65385} It decreases blood pressure in spontaneously hypertensive, but not normotensive, rats when administered at a dose of 50 mg/kg.{65386}