Formulation: A solution in methyl acetate
Formal Name: 2-(propyl-1,1-d2)-pentanoic-3,3-d2 acid
Purity: ≥99% deuterated forms (d1-d4)
Formula Markup: C8H12D4O2
Formula Weight: 148,2
Shelf life (days): 730
CAS Number: 87745-17-3
Notes: Valproic acid-d4 is intended for use as an internal standard for the quantification of valproic acid (Item Nos. 35739 / 13033) by GC- or LC-MS. Valproic acid is an analog of the natural fatty acid valeric acid that inhibits class I histone deacetylases (HDACs) with IC50 values of approximately 2 mM.{17456} It decreases the number of axon branches in sensory neurons isolated from newborn rat dorsal root ganglia, an effect that is reversed by inositol-1,4,5-trisphosphate (1,4,5-IP3).{9786} In vivo, valproic acid inhibits amyloid-β deposition and neuritic plaque formation and decreases escape latency in Morris water maze, indicating improved memory performance, in the APP23 transgenic mouse model of Alzheimer's disease.{17458} Valproic acid has anticonvulsant activity in the pentylenetetrazole seizure threshold test in mice (ED50 = 0.71 mmol/kg) but induces neurotoxicity when administered at doses greater than or equal to 1.2 mmol/kg.{42211} Formulations containing valproic acid have been used in the treatment of bipolar disorder and various seizure disorders.
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