Rhosin (hydrochloride), CAS 1281870-42-5

Formulation: A solid

Formal Name: 2-(6-quinoxalinylmethylene)hydrazide, D-Tryptophan, monohydrochloride

Purity: ≥98%

Formula Markup: C20H18N6O • HCl

Formula Weight: 394,9

Shelf life (days): 1460

CAS Number: 1281870-42-5

Notes: Rhosin is an inhibitor of the protein-protein interaction between Rho and guanine nucleotide exchange factors (GEFs).{64564} It inhibits RhoA activity when used at concentrations of 10 and 30 µM and selectively reduces the number and size of MCF-7 breast cancer cell mammospheres over MCF-10A non-cancerous cell mammospheres. It also inhibits migration and invasion of MCF-7 cells and human mammary epithelial cells expressing RhoC. Rhosin (30 µM) increases neurite outgrowth in PC12 cells. It prevents social defeat stress-induced hyperexcitability and increases spine density in nucleus accumbens dopamine 1 receptor medium spiny neurons (D1-MSNs) when administered post-social defeat stress in a mouse model of depression at a dose of 40 mg/kg.{64565} It also prevents social defeat stress-induced social avoidance and reductions in sucrose preference in the same model.

• SKU: CAY36415-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 36415-5
• Green Labware: No
• Package Unit: 5 mg
• Quantity Unit: STK
• Application: Reinstoffe