Formulation: Lyophilized from sterile 20 mM Tris,150 mM sodium chloride, pH 8.0, with 10% glycerol
Purity: ≥90% estimated by SDS-PAGE
Formula Weight: 0
Shelf life (days): 365
Notes: Rift Valley fever virus (RVFV) is a single-stranded negative-sense RNA virus, member of the Phlebovirus genus, and mosquito-transmitted pathogen endemic to sub-Saharan Africa and the Arabian peninsula.{69742,69740,69741} The tripartite RNA genome of RVFV is composed of three segments: L, which encodes L protein, a single-polypeptide viral RNA-dependent RNA polymerase (RdRp), M, which encodes a single open reading frame (ORF) that produces the envelope glycoproteins Gn and Gc and non-structural proteins NSm and Gn/NSm fusion protein, and S, which is ambisense, encoding the nucleoprotein N in the genomic sense orientation and the non-structural protein and major virulence factor NSs in the antigenomic orientation.{69741,69740} RVFV glycoprotein Gc is a class II membrane fusion protein that mediates viral entry and is composed of three domains: domain I, which is a 10-stranded β-barrel that organizes the glycoprotein structure, β-stranded domain II, and IgC-like domain III.{69743} Cayman’s RVFV Glycoprotein Gc (Strain MP12) (recombinant) protein consists of 459 amino acids and has a calculated molecular weight of 50.1 kDa.
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