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Applications: Useful for studying enzyme kinetics and screening small molecular inhibitors for drug discovery and HTS applications.
Description: The ROS1 Kinase Assay Kit is designed to measure ROS1 activity for screening and profiling applications using Kinase-Glo® MAX as a detection reagent. The signal is measured using a luminometer or a microplate reader capable of reading chemiluminescence.
Storage Stability: This assay kit will perform optimally for up to 6 months from date of receipt when the materials are stored as directed.
Supplied As: The ROS1 Kinase Assay Kit comes in a convenient 96-well format, with enough purified ROS1, substrate IGF-1Rtide, ATP, and kinase assay buffer for 96 enzyme reactions.
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)
References: 1. Davies, Kurtis D., and Doebele , Robert C. "Molecular pathways: ROS1 fusion proteins in cancer." Clinical Cancer Research 15 (2013): 4040-4045.
2. Davies, Kurtis D., et al. "Identifying and targeting ROS1 gene fusions in non-small cell lung cancer." Clinical Cancer Research 17 (2012): 4570-4579.
3. Rimkunas, Victoria M., et al. "Analysis of receptor tyrosine kinase ROS1-positive tumors in non-small cell lung cancer: identification of a FIG-ROS1 fusion." Clinical Cancer Research16 (2012): 4449-4457.
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