Product Type: Inhibitor
CAS No.: 186692-46-6
MolecularFormula: C19H26N6O
Molecular Weight: 354,4
Source: Synthetic
Purity: >99% (TLC and HPLC); NMR (Conforms)
Solubility: May be dissolved in ethanol (10mg/mL); or DMSO (10mg/mL, warm)
Appearance: White to off-white solid
PubChem CID: 160355
Scientific Background: Roscovitine is a potent and selective inhibitor of cyclin-dependent kinases (CDKs). It is specifically selective for CDK1/cyclin B kinase, CDK2 and CDK5/p35. It inhibits M phase promoting factor kinase activity and affects calcium channel gating.
References: 1. De Azevedo, et al. (1997) Eur. J. Biochem. 243(1-2): 518–526.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.