Product Type: Agonist
CAS No.: 155141-29-0
MolecularFormula: C18H19N3O3S•C4H4O4
Molecular Weight: 473,5
Source: Synthetic
Purity: >98%
Solubility: Soluble in DMSO (3 mg/ml) or DMF (10 mg/ml)
Appearance: White to off-white solid
PubChem CID: 77999
Scientific Background: Rosiglitazone is a potent agonist for PPARγ with an EC50 of 43 nM for the human receptor. It is anti-diabetic, working as an insulin sensitizer by binding to the PPARγ receptors in fat cells and making the cells more responsive to insulin.
References: 1. Werner A.L., & Travaglini M.T. (2001) Pharmacotherapy. 21(9): 1082-99.2. McMorran M., and Vu D. (2001) CMAJ. 165(1): 82-3, 86-7.3. Malinowski J.M. & Bolesta S. (2000) Clin. Ther. 22(10): 1151-68.4. Cheng-Lai A., & Levine A. (2000) Heart Dis. 2(4): 326-33.5. Knock G.A., et al. (1999) Eur. J. Pharmacol. 368(1): 103-9.6. Balfour J.A., & Plosker G.L. (1999) Drugs. 57(6): 921-30.7. Parks D.J., et al. (1998) Bioorg. Med. Chem. Lett. 8(24): 3657-8.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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