RRP8 Polyclonal Antibody, Rabbit

Abbreviation: RRP8

Target Synonym: NML; KIAA0409

Conjugation: Unconjugated

UNIProt ID: O43159

Background: Essential component of the eNoSC (energy-dependent nucleolar silencing complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+/NADP(+ ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2 by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown.

Concentration: 1mg/mL

Immunogen: A synthetic peptide of human RRP8

Dilution: WB 1:500-1:2000

• SKU: ELSE-AB-92293-120
• Manufacturer: Elabscience Biotechnology
• Manufacturer SKU: ELA-E-AB-92293-120
• Green Labware: No
• Package Unit: 120 µl
• Quantity Unit: STK
• Reactivity: Human, Mouse (Murine), Rat (Rattus)
• Clonality: Polyclonal
• Application: Western Blotting
• Isotype: IgG
• Host: Rabbit