Specificity: S-100 from ox brain was used for immunization. This antibody reacts strongly with human S100-A and B. Extensive testing shows that this antibody gives strictly specific S-100 labeling of cryostat as well as formalin-fixed, paraffin-embedded section of human tissue. This antibody labels glial cells in the brain and ependymal cells. Moreover, Schwann cells of the peripheral nervous system are positive. Among tumors of the human central and peripheral nervous system, a positive reaction is seen in schwannomas and ependymomas, as well as in different grades of astrogliomas including glioblastomas. A large proportion of cells in human tumors originating from different salivary glands are stainable with anti-S-100. S-100 is present in almost all human benign and malignant melanocytic tumors of the skin and in metastases of human malignant melanomas.
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