S-(N-Methylsulfinylbutylthiocarbamoyl)-L-cysteine, CAS 364083-21-6

Formulation: A solid

Formal Name: S-[[[4-(methylsulfinyl)butyl]amino]thioxomethyl]-L-cysteine

Purity: ≥95%

Formula Markup: C9H18N2O3S3

Formula Weight: 298,4

Shelf life (days): 1460

CAS Number: 364083-21-6

Notes: S-(N-Methylsulfinylbutylthiocarbamoyl)-L-cysteine (SFN-Cys) is a isothiocyanate derivative and an active metabolite of the class I and II histone deacetylase (HDAC) inhibitor and anticancer agent sulforaphane (Item Nos. 10496 / 14797).{67487} It is formed from sulforaphane via DL-sulforaphane glutathione (Item No. 34731) and sulforaphane cysteinylglycine intermediates by mercapturic acid pathway enzymes. SFN-Cys (20 µM) reduces invasion and migration by U87MG and U373 MG glioblastoma cells in wound healing and chamber assays, respectively.{67488} It decreases levels of α-tubulin, βIII-tubulin, stathmin 1, and X-linked inhibitor of apoptosis (XIAP) in, as well as reduces cell density of, paclitaxel-resistant A549 lung cancer cells (A549/T) when used at a concentration of 45 µM.{67489} SFN-Cys (30 µM) induces apoptosis and cell cycle arrest at the G2/M phase in U87MG and U373 MG cells.{67490}

• SKU: CAY39555-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 39555-5
• Green Labware: No
• Package Unit: 5 mg
• Quantity Unit: STK