S1PL-IN-31, CAS 1538574-95-6

Formulation: A solid

Formal Name: 6-[(2R)-4-[7-chloro-4-(phenylmethyl)-1-phthalazinyl]-2-methyl-1-piperazinyl]-3-pyridinecarbonitrile

Purity: ≥98%

Formula Markup: C26H23ClN6

Formula Weight: 455

Shelf life (days): 1460

CAS Number: 1538574-95-6

Notes: S1PL-IN-31 is an inhibitor of sphingosine-1-phosphate (S1P) lyase (IC50 = 210 nM).{51526} It is also an antagonist of the Smoothened (Smo) receptor (IC50 = 440 nM). In vivo, S1PL-IN-31 (2 mg/kg per day) prevents cervical and thoracic lymphocyte infiltration and neuromuscular weakness in a rat model of experimental autoimmune encephalomyelitis (EAE) induced by the myelin oligodendrocyte glycoprotein (MOG) peptide MOG29-152. It reduces the total number of lymphocytes, as well as the levels of CD4+ T cells, CD8+ T cells, and B cells in rats. S1PL-IN-31 (100 mg/kg) increases S1P levels in the heart and lymph nodes of male and female rats and decreases heart rate in female rats when administered at doses of 3 and 10 mg/kg per day.{51527}

• SKU: CAY39826-10
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 39826-10
• Green Labware: No
• Package Unit: 10 mg
• Quantity Unit: STK