Product Type: Inhibitor
CAS No.: 1477949-42-0
MolecularFormula: C15H22N2O3
Molecular Weight: 278,4
Source: Synthetic
Purity: >98% (TLC); NMR (Conforms)
Solubility: May be dissolved in DMSO (25 mg/ml); or Ethanol (20 mg/ml)
Appearance: Off-white powder
PubChem CID: 72946782
Scientific Background: Santacruzamate A is a highly potent and selective inhibitor of HDAC2 isolated from the Panamanian marine cyanobacterium cf. Symploca (IC50=0.119 and 434 nM for HDAC2 and HDAC6 respectively) (1). It induces apoptosis and cancer cell death only in combination with other HDAC1 inhibitors (2). It has been been investigated as a potential therapeutic agent for breast cancer (3). Attenuates A fragment (A25-35)-induced toxicity in PC12 cells by enhancing ER stress tolerance4. Ameliorates Alzheimer’s disease-like pathology in mouse models (4).
References: 1. Pavlik C.M., et al. (2013) J. Nat. Prod. 76:20262.Zhou et al. H., (2018) Cell Prolif. 51(3):e124773. Damaskos C., et al. (2017) Anticancer Res. 37:354.Chen L., et al. (2019) Front. Cell. Neurosci. 13:61
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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