Product Description: SAR407899 hydrochloride is a selective, potent and ATP-competitive ROCK inhibitor, with an IC50 of 135 nM for ROCK-2, and Kis of 36 nM and 41 nM for human and rat ROCK-2, respectively.
Applications: Metabolism-protein/nucleotide metabolism
Formula: C14H17ClN2O2
References: [1]L?hn M, et al. Pharmacological characterization of SAR407899, a novel rho-kinase inhibitor. Hypertension. 2009 Sep;54(3):676-83./[2]Guagnini F, et al. Erectile properties of the Rho-kinase inhibitor SAR407899 in diabetic animals and human isolated corpora cavernosa. J Transl Med. 2012 Mar 23;10:59./[3]Chen W, et al. Screening RhoA/ROCK inhibitors for the ability to prevent chronic rejection of mouse cardiac allografts.Transpl Immunol. 2018 Jun 6. pii: S0966-3274(18)30029-7.
CAS Number: 923262-96-8
Molecular Weight: 280.75
Compound Purity: 99.14
Research Area: Metabolic Disease
Solubility: DMSO : 25 mg/mL (ultrasonic)/H2O : 50 mg/mL (ultrasonic)
Target: ROCK
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