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Applications: This kit is useful for detection of anti SARS-CoV-2 Spike RBD IgG in human serum
Background: The pandemic coronavirus disease 2019 (COVID-19) is caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). As a first step of the viral replication strategy, the virus attaches to the host cell surface before entering the cell. The Spike protein recognizes and binds to the Angiotensin-Converting Enzyme 2 (ACE2) receptor found on the surface of type I and II pneumocytes, endothelial cells, and ciliated bronchial epithelial cells. Drugs targeting the interaction between the Spike protein of SARS-CoV-2 and ACE2 may offer some protection against the viral infection.
Description: The SARS-CoV-2 IgG detection kit is designed for qualitative detection of human IgG antibodies in serum collected from individuals suspected of prior infection with the virus that causes COVID-19. This fast and simple ELISA uses the receptor binding domain (RBD) of the SARS-CoV-2 Spike protein (BPS Bioscience #100696) to identify IgG antibodies that indicate a previous infection with SARS-CoV-2.
Storage Stability: Up to 6 months from date of receipt, when stored as recommended.
Supplied As: The SARS-CoV-2 IgG Detection Kit (Colorimetric Anti-Spike RBD IgG detection) Detection Kit comes in a convenient 96-well format, with purified SARS-CoV-2 RBD protein and an HRP-conjugated anti-human Fc antibody for 100 binding reactions.
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)
References: Long, Q.-X., et al. 2020. Antibody responses to SARS-CoV-2 in patients with COVID-19. Nat. Med. (in press). https://doi.org/10.1038/s41591-020-0897-1
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